Clinical impact of immunomonitoring in the treatment of inflammatory bowel disease

Table 6 Trough levels associated with mucosal healing for infliximab

Study	n	Mean Infliximab Trough level μg/mL	Mean Infliximab Trough level μg/mL	P value	95%CI
		Mucosal Healing	No mucosal Healing
Paul et al[61]	52 (UC/CD)	Delta IFX > 0.5		0.0001
Ungar et al[63]	78 (UC/CD)	4.3	1.7	0.002
Imaeda et al[43]	45 (CD)	> 4.0			0.56-0.70
Reinisch et al[42]	123 (CD)	> 3.0			1.53-7.28
Colombel et al[64]	188 (CD)	3.51	1.72	0.0018
Papamichael et al[62]	101(UC)	> 15 (wk 6)		0.025
		> 2.1 (wk 14)		0.004

IFX: Infliximab; UC: Ulcerative colitis; CD: Crohn’s disease.