Hwangryunhaedok-tang induces the depolarization of pacemaker potentials through 5-HT3 and 5-HT4 receptors in cultured murine small intestine interstitial cells of Cajal

Figure 7 Effects of Phellodendri Cortex and Gardeniae Fructus on pacemaker potentials in cultured interstitial cells of Cajal from murine small intestine. A: Pacemaking activities of ICCs exposed to Phellodendri Cortex (30 μg/mL) in the current-clamp mode (I = 0); B: Phellodendri Cortex (10-100 μg/mL) concentration-dependently induced pacemaker potential depolarization. Responses to Phellodendri Cortex are summarized; C: Pacemaking activities of ICCs exposed to Gardeniae Fructus (30 μg/mL) in the current-clamp mode (I = 0); D: Gardeniae Fructus (10-100 μg/mL) concentration-dependently induced pacemaker potential depolarizations. Responses to Gardeniae Fructus are summarized; E: Frequency changes to Phellodendri Cortex and Gardeniae Fructus are summarized. Bars represent the means ± SEMs. ^aP < 0.05 and ^eP < 0.001: Significantly different from the control. CTRL: Control; PC: Phellodendri Cortex. GF: Gardeniae Fructus.