Hwangryunhaedok-tang induces the depolarization of pacemaker potentials through 5-HT3 and 5-HT4 receptors in cultured murine small intestine interstitial cells of Cajal

Figure 5 Effects of protein kinase C inhibitor and Rho kinase inhibitor on water extract of Hwangryunhaedok-tang-induced pacemaker potential depolarizations in cultured interstitial cells of Cajal from murine small intestine. Both (A) calphostin C (a PKC inhibitor) and (B) Y27631 (a Rho kinase inhibitor) had no effects on the pacemaker potentials; under these conditions, HHTE induced pacemaker potential depolarizations. C and D responses to HHTE in the presence of calphostin C or Y27631 are summarized. Bars represent the means ± SEMs. ^eP < 0.001: significantly different from the nontreated control. CTRL: Control; HHTE: Water extract of Hwangryunhaedok-tang; PKC: Protein kinase C.