Barrett’s oesophagus: Current controversies

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 28, 2017; 23(28): 5051-5067
Published online Jul 28, 2017. doi: 10.3748/wjg.v23.i28.5051

Table 4 Summary of molecular biomarkers predicting malignant progression

Biomarker	Phase	Sample size	End-point
Biomarker panels
8-gene methylation panel	3	195	High grade dysplasia/adenocarcinoma
DNA content abnormalities and loss of heterozygosity	4	243	Adenocarcinoma
Expert low grade dysplasia, aneuploidy, Aspergillus oryzae lectin	3	380	Adenocarcinoma
DNA content abnormalities
Aneupolidy/tetraploidy	4	322	Adenocarcinoma
Tumour suppressor loci
p53 loss of heterozygosity	4	256	Adenocarcinoma
p53 staining	4	48	High grade dysplasia/adenocarcinoma
Epigenetics
P16 methylation	3	53	HD/adenocarcinoma
Proliferation
Mcm2	3	27	Adenocarcinoma
Clonal diversity
Clonal diversity measures	4	239	Adenocarcinoma
Cell cycle markers
Cyclin A	3	48	High grade dysplasia/adenocarcinoma
Cyclin D1	3	307	Adenocarcinoma
Serum biomarkers
Leukocyte telomere length	4	300	Adenocarcinoma
Selenoprotein P	4	361	Adenocarcinoma

Citation: Amadi C, Gatenby P. Barrett’s oesophagus: Current controversies. World J Gastroenterol 2017; 23(28): 5051-5067
URL: https://www.wjgnet.com/1007-9327/full/v23/i28/5051.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i28.5051

Amadi C, Gatenby P. Barrett’s oesophagus: Current controversies. World J Gastroenterol 2017; 23(28): 5051-5067 [PMID: 28811703 DOI: 10.3748/wjg.v23.i28.5051]

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