Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease

Figure 4 Epistatic interaction of IL10RB and HO1 with IL-10 (three single nucleotide polymorphisms), IL10RA and STAT3 in pediatric inflammatory bowel disease. Graphic depiction of epistatic interaction of the IL-10 rs1800872, IL10RB rs2834167 and HO1 rs2071746. Of all the interaction models analyzed, a three SNP interaction (a1d2a3) for IL-10 rs1800872, IL10RB rs2834167 and HO1 rs2071746 is significant (Bp = 0.005). The levels of Bp values are shown in the bar as shades of blue color from none (Bp = 1) to high (Bp = 0.001). a1, d1, a2, d2, a3, d3: Letters, a and d, denote interaction models, additive and dominant respectively; Numbers 1, 2, and 3 are for IL-10 rs1800872, IL10RB rs2834167, and HO1 rs2071746, respectively. The contribution of a single SNP in an interaction model could be either a or d: a1 and d1 for SNP #1, a2 and d2 for SNP #2, and a3 and d3 for SNP #3. The interaction models for two and three SNPs are the combination of two and three SNPs (e.g., a1a2 for SNPs 1 and 2, and a1a2a3 for SNPs 1, 2, and 3). Bp: Bonferroni P value; SNP: Single nucleotide polymorphism.