Genetic polymorphisms predict response to anti-tumor necrosis factor treatment in Crohn’s disease

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2017; 23(27): 4958-4967
Published online Jul 21, 2017. doi: 10.3748/wjg.v23.i27.4958

Table 5 Univariable logistic regression data regarding factors associated with anti-tumor necrosis factor treatment failure

Covariate	P value
Demographic variables
Gender	NS
Race	NS
Montreal Classification
Age of onset (A) Montreal	NS
Location (L) Montreal	NS
Location (L4) upper GI Montreal	NS
Behavior (B) Montreal	0.13¹
Behavior (p) perianal Montreal	0.09¹
SNP variables
ATG16L1 rs10210302	NS
ATG16L1 rs2241880	NS
FAS Ligand rs763110	0.057¹
FAS Ligand rs763110 (TC + TT grouped)	0.02¹
IBD5 rs2522057	NS
FCGR 3A rs396991	NS
TNF gene (-308) rs1800629	0.13¹
TNF gene (-308) rs1800629 (AA + GA grouped)	0.099¹
TNF gene(-238) rs361525	NS

¹Covariates included in the subsequent multivariable analysis. TNF: Tumor necrosis factor; SNPs: Single nucleotide polymorphisms.

Citation: Netz U, Carter JV, Eichenberger MR, Dryden GW, Pan J, Rai SN, Galandiuk S. Genetic polymorphisms predict response to anti-tumor necrosis factor treatment in Crohn’s disease. World J Gastroenterol 2017; 23(27): 4958-4967
URL: https://www.wjgnet.com/1007-9327/full/v23/i27/4958.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i27.4958

Netz U, Carter JV, Eichenberger MR, Dryden GW, Pan J, Rai SN, Galandiuk S. Genetic polymorphisms predict response to anti-tumor necrosis factor treatment in Crohn’s disease. World J Gastroenterol 2017; 23(27): 4958-4967 [PMID: 28785150 DOI: 10.3748/wjg.v23.i27.4958]

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