Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease

Table 6 Gene-gene interaction between IL-10 with IL10RA, IL10RB, STAT3, or HO1 in pediatric inflammatory bowel disease

Gene	SNP	Epistatic model	IL10RA rs3135932, P = 0.160; Bp = 1	IL10RB rs2834167, P = 0.203; Bp = 1	STAT3 rs744166, P = 0.352; Bp = 1	HO1 rs2071746, P = 0.634; Bp = 1
IL-10	rs1800872	aa	P = 0.046; Bp = 1	P = 0.029; Bp = 1	P = 0.248; Bp = 1	P = 0.910; Bp = 1
		ad	P = 0.739; Bp = 1	P = 0.107; Bp = 1	P = 0.954; Bp = 1	P = 0.617; Bp = 1
		da	P = 0.056; Bp = 1	P = 0.376; Bp = 1	P = 0.117; Bp = 1	P = 0.569; Bp = 1
		dd	P = 0.126; Bp = 1	P = 0.168; Bp = 1	P = 0.036; Bp = 1	P = 0.671; Bp = 1
	rs3024498	aa	P = 0.330; Bp = 1	P = 0.062; Bp = 1	P = 0.143; Bp = 1	P = 0.898; Bp = 1
		ad	P = 0.068; Bp = 1	P = 0.629; Bp = 1	P = 0.032; Bp = 1	P = 0.840; Bp = 1
		da	P = 0.884; Bp = 1	P = 0.307; Bp = 1	P = 0.316; Bp = 1	P = 0.607; Bp = 1
		dd	P = 0.265; Bp = 1	P = 0.644; Bp = 1	P = 0.029; Bp = 1	P = 0.790; Bp = 1
	rs3024496	aa	P = 0.021; Bp = 0.433	P = 0.425; Bp = 1	P = 0.538; Bp = 1	P = 0.346; Bp = 1
		ad	P = 0.020; Bp = 0.426	P = 0.495; Bp = 1	P = 0.306; Bp = 1	P = 0.741; Bp = 1
		da	P = 0.081; Bp = 1	P = 0.189; Bp = 1	P = 0.234; Bp = 1	P = 0.297; Bp = 1
		dd	P = 0.967; Bp = 1	P = 0.570; Bp = 1	P = 0.402; Bp = 1	P = 0.457; Bp = 1
IL10RB	rs2834167	aa	P = 0.403; Bp = 1		P = 0.251; Bp = 1	P = 0.128; Bp = 1
		ad	P = 0.384; Bp = 1		P = 0.956; Bp = 1	P = 0.369; Bp = 1
		da	P = 0.518; Bp = 1		P = 0.776; Bp = 1	P = 0.0018; Bp = 0.039
		dd	P = 0.176; Bp = 1		P = 0.072; Bp = 1	P = 0.289; Bp = 1

Bp: Bonferroni P value; SNP: Single nucleotide polymorphism.