Naturally occurring mutations in the reverse transcriptase region of hepatitis B virus polymerase from treatment-naïve Korean patients infected with genotype C2

Table 6 Comparison of clinical features between patients with or without L80I

Clinical factors	Wild type (n = 126)	L80I (n = 5)	Total (n = 131)	P value
Age, yr, mean ± SD	45.8 ± 12.2	57.2 ± 8.1	45.7 ± 12.3	0.043
Gender, Male	63.50%	100%	64.80%	NS
HBeAg negative	45.20%	60.00%	45.80%	NS
ALT (IU/L), mean ± SD	84.0 ± 96.8	68.6 ± 19.7	100.8 ± 191.2	NS
AST (IU/L), mean ± SD	100.9 ± 125.3	118.6 ± 65.0	113.2 ± 141.0	NS
HBV DNA	5.8 ± 1.7	6.7 ± 0.2	6.5 ± 1.7	< 0.001
HBsAg	3.4 ± 0.65	3.5 ± 0.32	3.4 ± 0.6	NS
CH: HCC, HCC (%)	59/67 (53.9)	0/5 (100)	59/72 (54.9)	0.036

HBV: Hepatitis B virus; CH: Chronic hepatitis; HCC: Hepatocellular carcinoma.