Basic Study
Copyright ©The Author(s) 2017.
World J Gastroenterol. Jun 21, 2017; 23(23): 4222-4232
Published online Jun 21, 2017. doi: 10.3748/wjg.v23.i23.4222
Table 4 Mutation site distributions and mutation rate in different sections of hepatitis B virus RT and overlapped hepatitis B surface antigen regions
Region (amino acid)No. of mutation siteMutation frequencyP value
Reverse transcriptaseDomain (22)9 (40.9)1.07%0.008
A-B interdomain (6)6 (100)7.50%-
Non A-B interdomain (14)10 (71.4)3.16%NS
Total (42)25 (59.5)2.68%-
HBsAgA-determinant (3)2 (66.6)3.81%
Non A-determinant (37)8 (21.6)0.55%< 0.001
Total (40)10 (28.5)0.80%-