Prevalence of IFNL3 rs4803217 single nucleotide polymorphism and clinical course of chronic hepatitis C

doi:10.3748/wjg.v23.i21.3815

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 7, 2017; 23(21): 3815-3824
Published online Jun 7, 2017. doi: 10.3748/wjg.v23.i21.3815

Table 5 Association between IFNL3 (IL28B) gene single nucleotide polymorphism and relapse after pegylated interferon alpha and ribavirin treatment in chronic hepatitis C patients

SNP	Allele/genotype	Relapse (n = 39), n (%)	Non-relapse (n = 38), n (%)	Relapse vs non-relapse	OR (95%CI)	P value
rs4803217 (C/A)	C/A	38 (48.72)/40 (51.28)	56 (73.68)/20 (26.32)	C vs A	0.339 (0.173-0.667)	0.001^a
	CC	7 (17.95)	21 (55.26)	CC vs CA + AA	0.177 (0.063-0.500)	0.0007^a
	CA	24 (61.54)	14 (36.84)	CC + CA vs AA	0.332 (0.081-1.364)	0.113
	TT	8 (20.51)	3 (7.89)	Dose of C allele	0.296 (0.134-0.653)	0.002^a
rs12979860 (C/T)	C/T	40 (51.28)/38 (48.72)	52 (68.42)/24 (31.58)	C vs T	0.486 (0.252-0.937)	0.030^a
	CC	8 (20.51)	18 (47.37)	CC vs CT + TT	0.287 (0.105-0.783)	0.013^a
	CT	24 (61.54)	16 (42.11)	CC + CT vs TT	0.538 (0.143-2.013)	0.351
	TT	7 (17.95)	4 (10.53)	Dose of C allele	0.442 (0.211-0.925)	0.028^a
rs8099917 (T/G)	T/G	56 (71.79)/22 (28.21)	52 (68.42)/24 (31.58)	T vs G	1.175 (0.589-2.344)	0.647
	TT	21 (53.85)	17 (44.74)	TT vs TG + GG	1.304 (0.526-3.233)	0.566
	TG	14 (35.90)	18 (47.37)	TT + TG vs GG	0.750 (0.156-3.560)	1.000
	GG	4 (10.26)	3 (7.89)	Dose of T allele	1.174 (0.582-2.365)	0.649
rs12980275 (A/G)	A/G	45 (57.69)/33 (42.31)	56 (73.68)/20 (26.32)	A vs G	0.487 (0.247-0.961)	0.037^a
	AA	12 (30.77)	22 (57.89)	AA vs AG + GG	0.323 (0.127-0.825)	0.017^a
	AG	21 (53.85)	12 (31.58)	AA + AG vs GG	0.647 (0.167-2.503)	0.737
	GG	6 (15.38)	4 (10.53)	Dose of A allele	0.495 (0.245-0.998)	0.046^a

^aP < 0.05. SVR: Sustained virological response.

Citation: Świątek-Kościelna B, Kałużna E, Strauss E, Nowak J, Bereszyńska I, Gowin E, Wysocki J, Rembowska J, Barcińska D, Mozer-Lisewska I, Januszkiewicz-Lewandowska D. Prevalence of IFNL3 rs4803217 single nucleotide polymorphism and clinical course of chronic hepatitis C. World J Gastroenterol 2017; 23(21): 3815-3824
URL: https://www.wjgnet.com/1007-9327/full/v23/i21/3815.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i21.3815