Hepatitis A virus infection and hepatitis A vaccination in human immunodeficiency virus-positive patients: A review

Table 5 Comparison of clinical manifestations of hepatitis A virus between human immunodeficiency virus-positive patients or human immunodeficiency virus-negative patients with acute hepatitis A

	HIV-positive patients	HIV-negative patients
Natural course of acute HAV infection
Incubation period (wk)	NA	2.5-5[91]
Duration of stool shedding (d)	NA	25 (HAV antigen)[105]
		81 (HAV RNA)[106]
Duration of viremia (d)	53 (10-89)[25]	22-95[25,106-108]
Laboratory findings
Peak T-bilirubin (mg/dL)	5.1-5.9[25]	5.7-8.7[25,92,93,95,98,99]
Peak AST (IU/L)	929-1339[25,57]	1231-2271[25,92,93,99]
Peak ALT (IU/L)	1995-2368[25,57]	1079-3442[25,92,93,99,100]
Duration of elevated AST/ALT (d)	63 ± 38[109]	51[92]
Peak ALP (IU/L)	807[25,57]	228-396[25,92]

HIV: Human immunodeficiency virus; ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; HAV: Hepatitis A virus; NA: Not available.