Copyright
©The Author(s) 2017.
World J Gastroenterol. Jan 14, 2017; 23(2): 204-215
Published online Jan 14, 2017. doi: 10.3748/wjg.v23.i2.204
Published online Jan 14, 2017. doi: 10.3748/wjg.v23.i2.204
Figure 5 Fat alters the metabolic capacity of hepatocytes.
Hepatocytes were cultured in fat or lean conditions for 7 d. A: CYP3A activity was measured in three donors by CYP3A-Glo assay (n = 3 per donor); B: P450 activity of cells was compared using an LC-MS/MS cocktail assay. Production of key metabolites from probe compounds was measured after 2 h exposure and normalised to total cellular protein content. Data is a mean (n = 3) ± SD, aP < 0.05.
- Citation: Kostrzewski T, Cornforth T, Snow SA, Ouro-Gnao L, Rowe C, Large EM, Hughes DJ. Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease. World J Gastroenterol 2017; 23(2): 204-215
- URL: https://www.wjgnet.com/1007-9327/full/v23/i2/204.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i2.204