Nissen fundoplication vs proton pump inhibitors for laryngopharyngeal reflux based on pH-monitoring and symptom-scale

Table 1 Baseline demographics, clinical characteristics and proportions for laparoscopic Nissen fundoplication and proton pump inhibitor groups

Characteristic/parameter	LNF	PPI	P value
No.	31	39
Age (yr)	47.2 ± 10.7	51.3 ± 12.5	0.218
Sex			0.670
Male	14 (45.2)	19 (48.7)
Female	17 (54.8)	20 (51.3)
BMI (kg/m2)	23.9 ± 3.8	25.0 ± 3.1	0.285
RSI score	15.3 ± 3.5	14.2 ± 4.0	0.759
Presenting complaint
Regurgitation1	21 (67.7)	26 (66.7)	0.926
Heartburn1	23 (74.2)	28 (71.8)	0.826
Cough	18 (58.1)	21 (53.8)	0.729
Mucus	14 (45.1)	12 (30.7)	0.222
Globus	27 (87.1)	20 (51.3)	0.0032
Hoarseness	12 (38.7)	10 (25.6)	0.248
Throat pain	12 (38.7)	10 (25.6)	0.248
Throat clearing	10 (32.2)	9 (23.1)	0.398

¹Represents gastroesophageal reflux disease typical symptoms;

²Represent statistical significant P values (P < 0.05). Values are given as mean ± SD or n (%). LNF: Laparoscopic Nissen fundoplication; PPI: Proton pump inhibitor; BMI: Body mass index; RSI: Reflux symptom index.