Review
Copyright ©The Author(s) 2017.
World J Gastroenterol. May 7, 2017; 23(17): 3030-3042
Published online May 7, 2017. doi: 10.3748/wjg.v23.i17.3030
Figure 3
Figure 3 Brain reward dopaminergic signaling between ventral tegmental area and nucleus accumbens neurons. Dopamine in the VTA area activates excitatory DRD1 in the NAC. Several genetic polymorphisms in the regulatory proteins DRD2, DAT1, and COMT modify the reward response to dopamine. VTA: Ventral tegmental area; NAC: Nucleus accumbens; DRD1: Dopamine receptor 1; DRD2: Dopamine receptor 2; DAT1: Dopamine transporter 1; COMT: Catechol-O-methyl-transferase; TH: Tyrosine hydroxylase.