Non-invasive evaluation of intestinal disorders: The role of elastographic techniques

Table 2 Summary of the feasibility studies on elastography in animal models

Ref.	Subjects		Results
Kim et al[11], 2008	Animal model (rats)	Technique	Strain difference of normal colon vs affected left colon P < 0.0002
	6 Left-sided chronic colitides (from TNBS)	Strain elastography (UEI)
	5 controls	Comparison	Significant correlation between Young’s modulus and strain r = 0.67, P < 0.0005
		Direct mechanical measurement, Histology
Stidham et al[10], 2011	Animal model (TNBS rats)	Technique	Strain values:
	5 acute colitides	Strain elastography (UEI)	controls vs acute inflammation P = 0.015,
	5 chronic fibrosis	Comparison	controls vs chronic fibrosis P = 0.001,
	5 controls	Histology	acute inflammation vs chronic fibrosis P = 0.037
			Strain ratio:
			acute inflammation vs chronic fibrosis P = 0.030
Dillman et al[45], 2013	Animal model	Technique	SW velocity ratio:
	6 acute colitides	Shear wave elastography (Shear wave speed imaging)	AUROC curve for differentiating fibrosis from inflammation 0.971
	8 chronic colitides/fibrosis
	3 controls	Comparison
		Histology

TNBS: Trinitrobenzenesulfonic acid; UEI: Ultrasound elasticity imaging; CD: Crohn’s disease; AUROC: Area under receiver operating characteristic; SW: Shear wave; VAS: Visual analogue scale.