Association between COX-2 -1195G>A polymorphism and gastrointestinal cancer risk: A meta-analysis

Table 3 Stratified analyses of the COX-2 -1195G>A polymorphism with risk of gastrointestinal cancers

	n	Allele model			Dominant model			Recessive model			Homozygous comparison			Heterozygous comparison
		(A vs G)			(AA/AG vs GG)			(AA vs GG/AG)			(AA vs GG)			(AG vs GG)
		OR (95%CI)	Ph	FPRP	OR (95%CI)	Ph	FPRP	OR (95%CI)	Ph	FPRP	OR (95%CI)	Ph	FPRP	OR (95% CI)	Ph	FPRP
Total	28	1.15 (1.04, 1.26)1	0.000	0.73	1.24 (1.06, 1.45)1	0	0.876	1.16 (1.04, 1.30)1	0.000	0.914	1.31 (1.08, 1.59)1	0.000	0.873	1.18 (1.04, 1.34)1	0.007	0.915
Type of cancer
Gastric cancer	11	1.35 (1.14, 1.59)1	0.000	0.266	1.54 (1.20, 1.96)1	0.000	0.519	1.43 (1.18, 1.72)1	0.002	0.174	1.80 (1.36, 2.39)1	0.000	0.318	1.35 (1.11, 1.65)1	0.038	0.799
Colorectal cancer	17	1.04 (0.94, 1.15)	0.000	0.998	1.05 (0.87, 1.28)	0.002	0.998	1.04 (0.93, 1.18)	0.000	0.998	1.05 (0.83, 1.32)	0.000	0.999	1.06 (0.90, 1.25)	0.060	0.998
Ethnicity
Asian	14	1.30 (1.14, 1.48)1	0.000	0.069	1.50 (1.23, 1.84)1	0.000	0.167	1.35 (1.14, 1.60)1	0.000	0.376	1.71 (1.33, 2.18)1	0.000	0.093	1.37 (1.15, 1.62)1	0.007	0.213
Caucasian	12	1.00 (0.89, 1.11)	0.000	0.999	0.91 (0.76, 1.08)	0.360	0.996	1.01 (0.89, 1.15)	0.000	0.999	0.91 (0.74, 1.11)	0.186	0.997	0.92 (0.77, 1.09)	0.749	0.997
Mixed	2	1.10 (0.93, 1.31)	0.612	0.997	1.13 (0.74, 1.73)	0.466	0.998	1.13 (0.91, 1.40)	0.781	0.996	1.20 (0.76, 1.88)	0.482	0.998	1.09 (0.69, 1.70)	0.534	0.999
Source of controls
PB	22	1.16 (1.06, 1.25)1	0.000	0.09	1.26 (1.09, 1.45)1	0.003	0.559	1.19 (1.07, 1.33)1	0.000	0.685	1.35 (1.13, 1.61)1	0.000	0.488	1.19 (1.04, 1.36)1	0.031	0.914
HB	6	1.12 (0.75, 1.67)	0.000	0.998	1.14 (0.60, 2.15)	0.000	0.999	1.08 (0.72, 1.63)	0.000	0.999	1.15 (0.54, 2.45)	0.000	0.999	1.12 (0.73, 1.71)	0.021	0.998
Study quality
High (> 9)	23	1.15 (1.06, 1.25)1	0.000	0.504	1.25 (1.09, 1.44)1	0.004	0.667	1.19 (1.07, 1.32)1	0.000	0.502	1.34 (1.12, 1.59)1	0.000	0.469	1.19 (1.04, 1.35)1	0.038	0.873
Low ( ≤ 9)	5	1.13 (0.68, 1.86)	0.000	0.999	1.17 (0.56, 2.45)	0.000	0.999	1.09 (0.65, 1.81)	0.000	0.999	1.17 (0.48, 2.88)	0.000	0.999	1.16 (0.71, 1.90)	0.011	0.998
Genotyping method
PCR-RFLP	16	1.23 (1.08, 1.40)1	0.000	0.633	1.46 (1.19, 1.78)1	0.000	0.231	1.24 (1.06, 1.46)1	0.000	0.909	1.58 (1.23, 2.02)1	0.000	0.436	1.35 (1.14, 1.60)1	0.014	0.376
Taqman	9	0.99 (0.90, 1.08)	0.049	0.999	0.97 (0.82, 1.15)	0.428	0.999	0.99 (0.89, 1.11)	0.063	0.999	0.97 (0.79, 1.19)	0.268	0.999	0.98 (0.82, 1.17)	0.669	0.999
Other technologies	3	1.36 (0.86, 2.17)	0.000	0.997	1.16 (0.58, 2.31)	0.008	0.999	1.52 (0.84, 2.75)	0.000	0.997	1.40 (0.55, 3.53)	0.000	0.999	0.99 (0.62, 1.57)	0.118	0.999

¹OR with statistical significance. n: Number of studies included; Ph: P value for heterogeneity; FPRP: False positive report probability.