Microbiome and pancreatic cancer: A comprehensive topic review of literature

Table 3 Tissue microbiome and pancreatic cancer

Ref.	Study design	Case sample size	Detection method and sample	Bacteria association	Outcome	Author conclusion
Nilsson et al[44], 2006, Sweden	Case-control	84	DNA genus specific PCR, surgical specimen	H. pylori	Helicobacter DNA detected in pancreas of 75% patients with adenocarcinoma, but not detected in any control	Helicobacter DNA, mostly H. pylori genus, commonly detected in pancreatic cancer
Takayama et al[45], 2007, Japan	Abstract	-	ELISA and western blot, Pre-clinical cell line	H. pylori	IL-8 and VEGF secretion and proliferation factors NF-kappa-B, AP-1, and serum response element of human pancreatic cells increased by H. pylori infection	H. pylori infection of human pancreatic cells may increase malignant potential of pancreatic cells
Mitsuhashi et al[46], 2015, Japan	Case-control	283	PCR, surgical specimen	Fusobacterium	Detected in 8.8% cases.	significantly shorter survival observed in the Fusobacterium species-positive group
					Median cancer-survival (mo) positive vs negative detection
					17.2 vs 32.5 for
					log-rank P = 0.021