Prognostic value of site-specific metastases in pancreatic adenocarcinoma: A Surveillance Epidemiology and End Results database analysis

Table 2 Multivariate analyses of overall survival and pancreatic cancer-specific survival in metastatic pancreatic cancer patients

Features	Overall survival		Pancreatic cancer-specific survival
	Hazard ratio(95%CI)	P value	Hazard ratio (95%CI)	P value
Age (yr)
< 65	1.00 (reference)		1.00 (reference)
> 65	1.343 (1.292-1.396)	< 0.0001	1.131 (1.083-1.181)	< 0.0001
Race
Black	1.00 (reference)		1.00 (reference)
White	0.913 (0.865-0.965)	0.001	0.924 (0.869-0.983)	0.013
Others	0.891 (0.818-0.971)	0.009	0.956 (0.870-1.052)	0.360
Gender
Female	1.00 (reference)		1.00 (reference)
Male	1.117 (1.075-1.160)	< 0.0001	1.087 (1.042-1.135)	< 0.0001
Marital status
Married	1.00 (reference)		1.00 (reference)
Unmarried	1.243 (1.196-1.291)	< 0.0001	1.222 (1.170-1.276)	< 0.0001
T stage
T1	1.00 (reference)		1.00 (reference)
T2	1.151 (1.015-1.304)	0.028	1.170 (1.015-1.349)	0.030
T3	1.014 (0.895-1.149)	0.826	1.033 (0.896-1.191)	0.652
T4	0.974 (0.857-1.107)	0.688	0.986 (0.853-1.141)	0.851
N stage
N0	1.00 (reference)		1.00 (reference)
N1	1.004 (0.962-1.049)	0.841	1.001 (0.954-1.051)	0.958
Surgery of the primary
No	1.00 (reference)		1.00 (reference)
Yes	0.573 (0.489-0.671)	< 0.0001	0.537 (0.448-0.643)	< 0.0001
Surgery of the metastases
No	1.00 (reference)		1.00 (reference)
Yes	0.773 (0.703-0.851)	< 0.0001	0.782 (0.703-0.871)	< 0.0001
Distant metastases
Multiple metastases	1.00 (reference)		1.00 (reference)
Single metastasis	1.080 (0.900-1.297)	0.409	1.049 (0.867-1.270)	0.619