Serum HER2 as a predictive biomarker for tissue HER2 status and prognosis in patients with gastric cancer

Table 1 Clinicopathological characteristics

Variables	No. of patients	Percent
Age (range, 23-89, yr)
≥ 60	126	52.7
< 60	113	47.3
Gender
Male	167	69.9
Female	72	30.1
Smoking status
Never	61	25.5
Ever	178	74.5
Tumor location
GEJ	41	17.2
Non-GEJ	198	82.8
Tumor size
≥ 5 cm	102	42.7
< 5 cm	137	57.3
pTNM stage
I	39	16.3
II	78	32.6
III	102	42.7
IV	20	8.4
Lauren classification
Intestinal type	104	43.5
Diffuse type	135	56.5
Tissue HER2 status (IHC/FISH)
Positive	39	16.3
Negative	200	83.7
Serum HER2 ECD (ng/mL), median (range)	10.5 (4.2-190.2)

GEJ: Gastroesophageal junction; HER2: Human epidermal growth factor receptor-2; ECD: Extracellular domain; IHC: Immunohistochemistry; FISH: Fluorescence in situ hybridization.