Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier

Figure 1 Sodium butyrate attenuates high-fat diet-induced obesity, liver injury and metabolic disturbance. A: Gross appearances of mice in the control, HF and HF + NaB groups; B: Liver index = liver weight/body weight × 100; C: Epididymal fat index = epididymal fat weight/body weight × 100; D: Body weight at 16 wk; E-H: Fasting serum glucose, fasting serum insulin, HOMA-IR and ISI of the three groups; I-K: Liver aminotransferases represent liver function; L: Body weight changes; M: Energy intake per mouse per week. Data represent means ± SEM. (n = 12 mice per group), ^aP < 0.05, ^bP < 0.01 and ^eP < 0.001.