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Copyright ©The Author(s) 2017.
World J Gastroenterol. Jan 7, 2017; 23(1): 42-47
Published online Jan 7, 2017. doi: 10.3748/wjg.v23.i1.42
Table 1 Antibiotics and dosages for empiric treatment of neutropenic enterocolitis
AntibioticsDosages
Adults with NE
Monotherapy
Piperacillin-tazobactam3.375 g IV every 6 h
Imipenem-cillastin500 mg IV every 6 h or 1 g IV every 6-8 h
Duotherapy
Ceftazidime1 g IV every 8-12 h
OROR
Cefepime1 g IV every 8 h
Plus Metronidazole1 g IV every 6 h
Children ( 1-12 yr of age) with NE
Monotherapy
Piperacillin-tazobactam(> 9 mo and < 40 kg) 300 mg/kg per day IV divided every 8 h
Imipenem-cillastin(> 3 mo) 60-100 mg/kg per day IV divided every 6 h maximum 2-4 g/d
Duotherapy
Ceftazidime90-150 mg/kg per day IV divided every 8 h - maximum 6 g/d or
OR50 mg/kg IV every 8 h - maximum: 2 g/dose
Cefepime
Plus Metronidazole30 mg/kg per day IV divided every 6 h - maximum 4 g/d