Copyright
©The Author(s) 2016.
World J Gastroenterol. Mar 7, 2016; 22(9): 2678-2700
Published online Mar 7, 2016. doi: 10.3748/wjg.v22.i9.2678
Published online Mar 7, 2016. doi: 10.3748/wjg.v22.i9.2678
Figure 3 Activation of quiescent pancreatic stellate cells in pancreatic cancer.
In the normal pancreas, pancreatic stellate cells are in the quiescent state (qPSCs) and located in the periacinar space. They have a stellate morphology and contain vitamin A lipid vacuoles. During carcinogenesis, they become activated (aPSCs). aPSCs are the most important cellular source of cancer-associated fibroblasts (CAFs) in PC. CAFs, characterized by a spindle-shaped morphology, are the main effector cells in the desmoplastic reaction, and they synthesize extracellular matrix (ECM) proteins. Further, they produce the growth factors and cytokines that promote cancer cell proliferation and migration.
- Citation: Nielsen MFB, Mortensen MB, Detlefsen S. Key players in pancreatic cancer-stroma interaction: Cancer-associated fibroblasts, endothelial and inflammatory cells. World J Gastroenterol 2016; 22(9): 2678-2700
- URL: https://www.wjgnet.com/1007-9327/full/v22/i9/2678.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i9.2678