miRNAs as new molecular insights into inflammatory bowel disease: Crucial regulators in autoimmunity and inflammation

Table 1 Aberrantly expressed miRNAs in inflammatory bowel disease

Sample type	Expression	miRNAs	Ref.
Ulcerative colitis vs healthy controls
Mucosal tissues	Upregulated	miR-7, miR-16, miR-20b, miR-21, miR-23a, miR-24, miR-29a, miR-29b, miR-31, miR-125b-1*, miR-126, miR-126*, miR-127-3p, miR-135b, miR-146a, miR-150, miR-155, miR-195, miR-206, miR-223, miR-324-3p, miR-424, and let-7f	[25,26,117-122]
	Downregulated	miR-188-5p, miR-192, miR-200b, miR-215, miR-320a, miR-346, miR-375, and miR-422b; miR-124 (pediatric cases)	[117,119,123,124]
Peripheral blood	Upregulated	miR-16, miR-21, miR-28-5p, miR-103-2*, miR-151-5p, miR-155, miR-188-5p, miR-199a-5p, miR-340*, miR-362-3p, miR-378, miR-422a, miR-500, miR-501-5p, miR-532-3p, miR-769-5p, miR-874, and miRplus-E1271	[125-127]
	Downregulated	miR-505*	[126]
Crohn’s disease vs healthy controls
Mucosal tissues	Upregulated	miR-9, miR-21, miR-22, miR-26a, miR-29b, miR-29c, miR-30b, miR-31, miR-34c-5p, miR-106a, miR-106b, miR-126, miR-126*, miR-127-3p, miR-130a, miR-133b, miR-146a, miR-146b-5p, miR-150, miR-155, miR-181c, miR-196a, miR-196, miR-206, miR-324-3p, miR-375, and miR-424	[119,121,130,131]
	Downregulated	miR-7 and miR-141	[128,129]
Peripheral blood	Upregulated	miR-16, miR-23a, miR-29a, miR-106a, miR-107, miR-126, miR-191, miR-199a-5p, miR-200c, miR-362-3p and miR-532-3p;	[125,133]
		miR-16, miR-20a, miR-21, miR-30e, miR-93, miR-106a, miR-140, miR-192, miR-195, miR-484, and let-7b (pediatric cases)