Coagulopathy and transfusion therapy in pediatric liver transplantation

Table 1 Hemostatic differences in the pediatric population

Parameters	Defects	Activity	Time to normalization
Procoagulant factors
Factors II, VII, IX, X (vitamin K-dependent)	↓ quantity	↓	6 mo
Fibrinogen	Dysfunctional	↓	1 yr
Platelet	Hyporesponsiveness	↓	2-4 wk
vWF	↑ quantity/Hyperfunction	↑	/
Factor VIII	↑ quantity	↑	/
Anticoagulant factors
AT-III	↓ quantity/dysfunctional	↓	6 mo
Heparin Cofactor II	↓ quantity	↓	6 mo
TFPI	↓ quantity	↓	6 mo
α2-antiplasmin	↓ quantity	↓	6 mo
α1-antitrypsin	↓ quantity	↓	6 mo
C 1 esterase inhibitor	↓ quantity	↓	6 mo
Protein C	↓ quantity	↓	6 mo
Protein S	↓ quantity	↓	6 mo
α2-macroglobulin	↑ quantity	↑	6 mo