Hepatosplenic T-cell lymphoma in a 47-year-old Crohn’s disease patient on thiopurine monotherapy

Table 3 Cases of γδ-hepatosplenic T-cell lymphoma in patients with Crohn’s disease on thiopurine monotherapy

Index	Age, sex	Years of thiopurine	Presentation	Treatment	Survival (mo)
		treatment (type)
Index case	47, M	14 (AZT)	HSM, icterus, anemia, thrombocytopenia	Ch. (CHOP)	< 1
Selvaraj et al[7] 2013 (AERS 6751796)	18, M	< 1 (AZT, 6MP)	NS	NS	7
Selvaraj et al[7] 2013 (AERS 7554658)	13, M	NS (6MP)	NS	NS	NS
Fowler et al[18] 2010	19, M	6 (AZT)	SM, leucocytopenia	Ch. (NS) + splenectomy	4
Fowler et al[18] 2010	22, M	8 (6MP)	SM, night sweats, fever, abdominal tenderness	Ch. (NS)	Survival
Ochenrider et al[8] 2010	18, M	5 (6MP)	Fever, night sweats, SM, anemia, thrombocytopenia	Ch. (Pentostatin, ICE) + auto-SCT	7
Humphreys et al[19] 2008	27, F	5 (AZT)	Fever, nights sweats, pancytopenia, HSM	Interferon-α	> 31
Zeidan et al[20] 2007	31, M	6 (6MP)1	Chills, SM, fever, pancytopenia	Ch. (CHOP, cytarabine, ESHAP)	7
Falchook et al[15] 2006	NS	NS (6MP)	SM	Ch. (NS)	NS
Mittal et al[21] 2006	18, M	6 (AZT)	Fever, pancytopenia, HSM	Ch. (IVE, ESHAP, alemtuzumab	NS
				fludarabine) + allo-SCT
Navarro et al[22] 2003	35, M	5.6 (AZT)	Fever, night sweats, HSM, anemia, thrombocytopenia	Ch. (NS) + splenectomy	NS
Lémann et al[23] 1998	NS	4 (AZT)	NS	NS	NS

¹Received one single gift infliximab 51 mo before presentation, therefore considered as TNF-α inhibitor naive. AERS: Adverse Event Reporting System; AZT: Azathioprine; Ch.: Chemotherapy; CHOP: Cyclophosphamide, hydroxydoxorubicin, vincristine and prednisone; EHSAP: Etoposide, methylprednisolone, cytarabin, cisplatin; ICE: Ifosphamide, carboplatin, etoposide; IVE: Ifosphamide, carboplatin and etoposide; NS: Not specified; (H)SM: (hepato)splenomegaly; SCT: Stem cell transplantation; 6MP: 6-mercaptopurine.