Clinical features of acute hepatitis E super-infections on chronic hepatitis B

Table 4 Clinical features and laboratory data for patients with non-cirrhotic hepatitis B virus-hepatitis E virus co-infections n (%)

Characteristic	IT	IC	LC	RA	P value
	(n = 38)	(n = 27)	(n = 16)	(n = 53)
Baseline characteristics
Age (yr ) (Q1-Q3)	43 (30-52)	42 (34-51)	48 (39.3-58.8)	47 (36.0-56.5)	0.134
Male sex	17 (44.7)	22 (81.5)	13 (81.3)	41 (77.4)	< 0.010
Alcohol	7 (18.4)	5 (18.5)	5 (31.3)	20 (37.7)	0.136
Smoker	8 (21.1)	8 (29.6)	4 (25)	22 (41.5)	0.191
Clinical features
Jaundice > 10 ULN	6 (15.8)	6 (22.2)	6 (37.5)	25 (47.2)	< 0.010
Ascites	4 (10.5)	3 (11.1)	0	14 (26.4)	< 0.050
Infection	4 (10.5)	2 (7.4)	4 (25)	16 (30.2)	< 0.050
HE	1 (2.6)	1 (3.7)	0	13 (24.5)	< 0.010
Outcomes of disease
Severe disease	5 (13.2)	6 (22.2)	5 (31.3)	22 (41.5)	< 0.050
Mortality	1 (2.6)	0	0	9 (17)	< 0.010
Laboratory parameters
ALT (IU/L)	276.5 (77.5-520.5)	454 (214-822)	597.5 (156.75-1188.5)	447 (70-1034.5)	0.231
AST (IU/L)	162 (66.3-471.0)	186 (108-527)	266 (55.5-841.0)	200 (70.5-421.0)	0.854
Tbil (μmol/L)	22.1 (10.5-42.9)	38.8 (15.0-162.3)	160.3 (63.9-205.5)	148.4 (29.8-339.0)	< 0.001
ALB (g/dL)	38.4 (35.0-40.8)	39.4 (35.1-42.0)	36.5 (32.9-39.4)	36.5 (33.5-41.2)	0.199
INR	1.1 (1.0-1.2)	1.1 (1.0-1.2)	1.1 (0.9-1.3)	1.1 (1-2)	< 0.050
LEU count (109/L)	5 (4.3-6.5)	6.2 (5.0-6.9)	7.2 (5.4-9.0)	6.1 (4.4-7.1)	< 0.050
Platelet count (109/L)	155 (102.3-205.3)	149 (103-190)	177.5 (124.3-200.0)	126 (93-159)	0.072
NEU count (109/L)	2.7 (2.3-3.7)	3.4 (2.8-4.2)	3.9 (2.8-5.5)	3.7 (2.1-4.8)	0.144

Data are presented as median (Q1-Q3) and number of patients (%). Severe disease was defined as liver failure and/or liver decompensation. ALB: Albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; HE: Hepatic encephalopathy; INR: International normalized ratio; LEU: Leukocytes; NEU: Neutrophil; Tbil: Total bilirubin; ULN: Upper limit of normal.