Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma

Table 4 Significant DNA methylation alterations of age-related CpG sites in colorectal cancer samples compared to adenoma tissue

cgID	Gene symbol	P value	Δβ (CRC - AD)
cg08965235	LTBP3	9.09 × 10-4	-0.11
cg00945507	SEC61G	1.64 × 10-5	0.10
cg15974053	HSD17B14	2.27 × 10-3	0.10
cg24262469	TIPARP	5.33 × 10-8	0.10
cg07158339	FXN	1.84 × 10-7	0.10
cg11314684	AKT3	4.52 × 10-4	0.10
cg03578041	LARP6	2.57 × 10-9	0.10
cg17853587	NDST3	5.94 × 10-4	0.10
cg07408456	PGLYRP2	1.51 × 10-7	0.11
cg02580606	KRT33B	1.22 × 10-4	0.11
cg03019000	TEX264	5.39 × 10-5	0.11
cg27319898	ZNF804B	0.023	0.12
cg00436603	CYP2E1	1.97 × 10-6	0.12
cg15804973	MAP3K5	6.27 × 10-12	0.12
cg06117855	CLEC3B	1.73 × 10-7	0.13
cg24126851	DCHS1	3.58 × 10-8	0.13
cg16034652	UNC79	4.23 × 10-11	0.13
cg01262913	DSCR9	1.64 × 10-8	0.13
cg26372517	TFAP2E	9.80 × 10-6	0.13
cg03270204	DDR1	4.24 × 10-7	0.13
cg17589341	SLC14A1	7.35 × 10-10	0.13
cg22679120	SNX8	8.16 × 10-9	0.14
cg20828084	CEMIP	2.00 × 10-8	0.14
cg19305227	SLC28A2	1.11 × 10-6	0.14
cg00168942	GJD4	1.18 × 10-7	0.14
cg13038560	C2orf47	8.96 × 10-8	0.15
cg26614073	SCAP	1.33 × 10-9	0.15
cg19346193	UROS	2.09 × 10-8	0.16
cg00075967	STRA6	4.87 × 10-7	0.16
cg03103192	SPATA18	6.07 × 10-12	0.16
cg10345936	SLC36A2	4.09 × 10-6	0.16
cg17099569	GLI2	9.04 × 10-7	0.16
cg04126866	C10orf99	4.23 × 10-10	0.18
cg00091693	KRT20	1.17 × 10-8	0.19

N: Normal; Ad: Adenoma; CRC: Colorectal cancer.