Fecal microbial transplant for the treatment of pediatric inflammatory bowel disease

Table 5 Study characteristics and outcomes of published adult cohort studies of fecal microbial transplant for inflammatory bowel disease

Ref.	Clinical outcome	Follow-up
Wang et al[62], 2014	Clinical remission (1/2: 1 mo, 3 mo);	3 mo
	Clinical response (2/2: 1 wk)
Kump et al[49], 2013	Clinical remission (0/6: 90 d);	3 mo
	Clinical response (6/6: 2 wk; 4/6: stool frequency increased: 30 d; 2/6 sustained improvement: 90 d);
	Total colectomy (1/6), total proctocolectomy (2/6)
Wei et al[63], 2015	Mayo score: decreased from 5.80 ± 1.87 to 1.50 ± 1.35 (P < 0.01)	1 mo
Angelberger et al[26], 2013	Clinical remission (0/5: 12 wk);	3 mo
	Clinical response (1/5: 12 wk);
	Further deterioration (2/5: 4 wk)
Scaldaferri et al[64], 2015	Clinical remission (2/8: 2 wk; 2/8: 6 wk; 3/8: 12 wk);	3 mo
	Clinical response (2/8: 2 wk; 4/8: 6 wk; 4/8: 12 wk);
	Endoscopic response (2/6)
Ren et al[65], 2015	Mayo score: 11 patients achieved reduction of score	1-7 mo
Cui et al[50], 2015	Clinical improvement and steroid-free remission: 8/14;	3-18 mo
	Long-term remission: 4/14
Damman et al[66], 2015	Clinical remission (1/6: 4 wk; 0/6: 3 mo);	Not reported
	Worsening symptoms (6/6: 3 mo);
	Histology score improvement (5/6: 4 wk)
Borody et al[23], 2012	Complete clinical remission: 42/62;	3 mo
	Partial response: 15/62; Failure: 5/62;
	Normalization of mucosa: 8/21
Kump et al[49], 2013	Mayo score decrease > 3 points (5/9: 90 d);	1 mo
	Sustained mucosal healing: 1/9;
	Failure to sustain clinical improvement: 4/9
Landy et al[67], 2013	Clinical remission: 0/8;	1 mo
	Improvement in Cleveland Global Quality of Life score: 0/8

Adapted from Shi et al[48], 2016.