Therapeutic approaches for portal biliopathy: A systematic review

Table 2 Endoscopic management of portal biliopathy: summary of case series

Ref.	No. of patients	Biliary abnormalities	First treatment	Follow-up	Further treatments	Complications/outcome
Bhatia et al[27], 1995	4 symptomatic	Stenosis + stones 3 CBD stones 4	ES + SE + NBD 4	3-8 mo	Multiple ERCP 4	None
Perlemuter et al[20], 1996	8 symptomatic	Stenosis 8 CBD stones 2 Cholangitis 1	ES+NBD 3 BD 1 PSS 1 UDCA 2	6-60 mo	Multiple ES 1	Death 2 (cholangitis 1; stroke 1)
Condat et al[3], 2003	7 symptomatic	Cholecystitis/right hypocondrial pain 4 Cholangitis 1 Stenosis 2	Cholecystostomy + SE 1 Stent 1 BA + PTBD 1 UDCA 4	4-25 mo	-	Haemobilia 1
Sezgin et al[28], 2003	10 symptomatic	Stenosis 9 IE stones 1	ES + stent 10 NBD 4 BD 4	3.3 yr (range 1-7)	Multiple ERCP 5	Haemobilia 1 Cholangitis 5 Death 1
Dumortier et al[22], 2003	6 symptomatic	Stenosis 5 CBD stones 2	ES 5 BD 5 SE 2 Stent 1	10 mo (range 2 d-18 mo)	Multiple ERCP + PSS 4	Cholangitis 1 Cholecystitis 4
Khare et al[25], 2005	13 symptomatic	Stenosis 10 CBD stones 8	Stent 4 BD 6 SE 4	-	PSS 8 BA 1 Multiple ERCP 2 Splenectomy + devasc 2	Death 1
Dhiman et al[29], 2007	12 symptomatic	Stenosis 7 CBD stones 5 CBD varices 1 Mirizzi’ssdr 1	PSS 5 ES 3 ES + BD 2 Stent 4	19 mo (6-132 mo)	Multiple ERCP in pts initially treated with stent	Cholangitis in 2 pts treated with stent
Vibert et al[30], 2007	19 symptomatic	IE biliary dilation 9 IE stones 7 CBD stones 4	PSS group: PTBD 1 SRS 10 NPSS group: ES + stent 2 ES + SE 1 PTBD 6 BA 4	19 pts 8.3 yr	PSS group: BA 5 NPSS group PTBD 1 after ERCP and 4 after BA	Resolution 17 Death 3
Oo et al[17], 2009	13 symptomatic	Stenosis 13 CBD stones 10 GB stones 11	UDCA 1 Stent 7 ES + SE 1 Failed ERCP 4	2 yr (1-18 aa)	Metallic stent 3 Stent exchange 2 PSS 3 (2 TIPS, 1 surgical) LT 1	Haemobilia 2 Sepsis 3
Llop et al[1], 2011	14 symptomatic	Stenosis 14 CBD stones 6 GB stones 2	ES + SE 6 ES + UDCA 2 Cholecystectomy 2	-	Multiple ERCP 1 BA 1	-
Saraswat et al[24], 2013	20 symptomatic	Stenosis 20 CBD stones 8 GB stones 6	ES + SE 8 Stent 9 BD + stent 11	18 mesi (range 3-188)	Multiple ERCP 11	In 130 procedures: Cholangitis 40 Haemobilia 9
Ramchandani et al[31], 2013	5 symptomatic	CBD stenosis 2 CHD stenosis 1 CBD stones 2	Metallic stent 1 Plastic stent 2 BD + stent 1 Intracholedocal lithotripsy 1	6-7 mo	SRS 2 Stent Exchange 1	- Resolution 5
Cellich et al[23], 2015	8 symptomatic 1 asymptomatic	Stenosis 7 CBD stones 3 GB stones 1	ES 7 BD 4 SE 2 Stent 7	-	PSS 1 Stent exchange 3 BA 3	Cholangitis 3 Haemobilia 1

CBD: Common bile duct; GB: Gallbladder; IE: Intrahepatic; ES: Endoscopic sphincterotomy; SE: Stone extraction; NBD: Nasobiliary drainage; BD: Balloon dilation; PSS: Porto-systemic shunt; NPSS: No porto-systemic shunt; UDCA: Ursodeoxycholic acid; ERCP: Endoscopic retrograde cholangio-pancreatography; BA: Bilioenteric anastomosis; SRS: Splenorenal shunt; LT: Liver transplantation; TIPS: Transjugular intrahepatic porto-systemic shunt.