Naringenin protects against isoniazid- and rifampicin-induced apoptosis in hepatic injury

Figure 3 Naringenin pretreatment protects against isoniazid- and rifampicin-induced hepatocytes apoptosis. A-D: Apoptosis was detected with TUNEL staining of liver sections from mice treated with NSS (A), INH and RIF (B), or pretreated with NRG (50 or 100 mg/kg) before INH and RIF challenge (C and D). The number of TUNEL positive cells (arrow) was counted in six randomly selected areas from each tissue section at magnification × 400; E: All data are expressed as mean ± SEM for six samples per group. ^bP < 0.01 vs control group, ^dP < 0.01 vs INH and RIF group. NRG: Naringenin; INH: Isoniazid; RIF: Rifampicin.