Increased CD4+CD45RA-FoxP3low cells alter the balance between Treg and Th17 cells in colitis mice

Figure 4 FoxP3⁺IL17A⁺ and FoxP3⁺IL17A^- cell characteristics in healthy control mice and ulcerative colitis mice samples of peripheral blood monocytes, spleen, mesenteric lymph node, lamina propria of jejunum, and colon. A: FACS analysis of FoxP3⁺IL17A⁺ and FoxP3⁺IL17A^- cells in HC and UC samples gated for CD4⁺CD25⁺ T cells; B: Percentage of FoxP3⁺IL17A⁺ cells in HC and UC samples; C: Percentages of FoxP3⁺IL17A^- cells in HC and UC samples; D: FoxP3⁺IL17A⁺ cell distribution in different HC and UC samples. ^aP < 0.05 vs control, ^bP < 0.01 vs control, ^cP < 0.001 vs control, ^dP < 0.05 vs LPC, ^eP < 0.01 vs LPC, ^fP < 0.001 vs LPC. PBMC: Peripheral blood monocytes; MLN: Mesenteric lymph node; FrI cells: CD4⁺CD45RA⁺FoxP3^low; FrII cells: CD4⁺CD45RA^-FoxP3^high; FrIII cells: CD4⁺CD45RA^-FoxP3^low; HC: Healthy control mice; UC: Ulcerative colitis mice; LPJ: Lamina propria of jejunum; LPC: Lamina propria of colon.