Genetic polymorphism in CD14 gene, a co-receptor of TLR4 associated with non-alcoholic fatty liver disease

Table 7 Comparison of non-alcoholic fatty liver disease patients with and without CD14 C (-159) T polymorphism

CD14 C (-159) T polymorphism (NAFLD = 200)
Parameters	Without polymorphism (n = 106)	With polymorphism (n = 94)	P value
TNF-α (pg/mL) (n = 200)	56 (34-80)	62 (40-112)	0.04
Adiponectin (pg/mL)	745 (649-893)	745 (634-928)	0.93
(n = 200)
IL-1β (pg/mL)	43 (32-47)	43 (25-47)	0.53
(n = 200)
HOMA-IR (n = 200)	1.9 (1.3-2.7)	1.8 (1.4-3.8)	0.34
MS (n = 200)
≥ 3 components	43 (40.5%)	35 (37.2%)	0.63
ALT (IU/L)	83 (68-108)	95 (-130)	0.016
NAS score (n = 60)	8	6	0.94
No NASH	11	10
Borderline NASH	13	12
NASH
Severity of steatosis (n = 60)
1	9	6
2	14	15	0.733
3	9	7
Severity of fibrosis (n = 60)
0	13	11	0.90
1	16	13
2	1	2
3	2	2

TNF-α: Tumor necrosis factor-α; NASH: Non-alcoholic steatohepatitis; ALT: Alanine aminotransferases; NAFLD: Non-alcoholic fatty liver disease.