Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 14, 2016; 22(42): 9300-9313
Published online Nov 14, 2016. doi: 10.3748/wjg.v22.i42.9300

Table 4 Prediction of response to anti-tumor necrosis factor therapy - possible biomarkers

Material/method	Predictor for response	Disease	Ref.
Intestinal biopsies	IL1B (upregulated in non-responders)	CD	[54]
Intestinal biopsies	IL17A (upregulated in non-responders)	CD	[54]
Intestinal biopsies	IL13RA2	CD and UC	[16]
	PTGS2
	WNT5A
Blood	high CAI	UC	[17]
	negative ANCA
	IL23R
Blood	High API	CD	[83]
Blood	C-reactive protein	CD and UC	[84]
Intestinal biopsies	TNFRSF11B (osteoprotegerin)	UC	[85]
	STC1 (stanniocalcin-1)
	PTGS2 (prostaglandin-endoperoxide synthase 2)
	IL13Ralpha2 (IL13R alpha 2)
	IL11 (IL-11)
SPECT	High apoptosis rate	CD	[80]
Endoscopic molecular imaging	High mucosal mTNF expression in vivo	CD	[18]

CD: Crohn’s disease; UC: Ulcerative colitis; SPECT: Single-photon emission computer tomography.

Citation: Billmeier U, Dieterich W, Neurath MF, Atreya R. Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases. World J Gastroenterol 2016; 22(42): 9300-9313
URL: https://www.wjgnet.com/1007-9327/full/v22/i42/9300.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i42.9300

Billmeier U, Dieterich W, Neurath MF, Atreya R. Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases. World J Gastroenterol 2016; 22(42): 9300-9313 [PMID: 27895418 DOI: 10.3748/wjg.v22.i42.9300]

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