Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis

Table 3 Performance characteristics of various scoring systems in predicting 28- and 90-d mortality

Scores	AUROC (95%CI)	Cutoff	Sensitivity	Specificity	PPV	NPV
28-d mortality
CLIF-SOFA	0.86 (0.81-0.90)	8	78.1%	79.7%	34.7%	96.4%
CLIF-C OF	0.89 (0.84-0.92)	10	68.8%	91.4%	52.4%	95.5%
DF	0.79 (0.74-0.84)	32	81.3%	50.9%	18.6%	95.2%
ABIC	0.78 (0.72-0.83)	9	43.7%	93.5%	48.3%	92.3%
GAHS	0.81 (0.76-0.86)	9	65.6%	83.2%	35.0%	94.6%
MELD	0.83 (0.78-0.88)	21	87.5%	57.8%	22.2%	97.1%
MELD-Na	0.83 (0.78-0.88)	28	68.8%	80.2%	32.4%	94.9%
90-d mortality
CLIF-SOFA	0.81 (0.76-0.86)	8	66.7%	84.3%	54.8%	89.8%
CLIF-C OF	0.83 (0.78-0.88)	10	52.9%	94.4%	73.0%	87.5%
DF	0.77 (0.71-0.82)	32	78.4%	53.4%	32.5%	89.6%
ABIC	0.78 (0.72-0.83)	9	39.2%	96.1%	74.1%	84.7%
GAHS	0.82 (0.77-0.87)	9	68.6%	88.8%	63.6%	90.8%
MELD	0.81 (0.77-0.87)	21	82.4%	61.8%	38.2%	92.4%
MELD-Na	0.87 (0.82-0.91)	28	66.7%	87.6%	60.7%	90.2%

AUROC: Area under receiver operating characteristic curve; PPV: Positive predictive value; NPV: Negative predictive value; CLIF-SOFA: Chronic Liver Failure-Sequential Organ Failure Assessment; CLIF-C OF: Chronic Liver Failure Consortium Organ Failure; DF: Discriminant function; ABIC: Age, bilirubin, INR, creatinine; GAHS: Glasgow Alcoholic Hepatitis Score; MELD: Model for end-stage liver disease; MELD-Na: Modified MELD including sodium.