Hepatic non-parenchymal cells: Master regulators of alcoholic liver disease?

Figure 2 Freshly isolated hepatic stellate cells from liquid ethanol-fed mice were susceptible to natural killer cell killing. A: Mice were fed with 5% liquid ethanol diet for 8 wk. Hepatic stellate cells (HSCs) were freshly isolated from ethanol-fed mice and then co-cultured with natural killer (NK) cells. NK cells were stained with NKG2D antibody and HSCs were stained with RAE1; B: Schematic overview of NKT cell cytotoxicity against activated HSCs via interferon (IFN)-γ-dependent manner.