Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness

Table 2 Cut-off values of stiffness in relation to METAVIR score based on the prevalence of disease in studies conducted before 2009

		Cut off values of stiffness
Authors	Aetiology	≥F2	≥F3	≥F4	PPV/NPV (%)
Castera et al[50]	HCV	7.1			95/48
			9.5		87/81
				12.5	77/95
Ziol et al[51]
	HCV	8.8			88/56
			9.6		71/93
				14.6	78/97
Carrion et al[52]
	HCV post-LT	8.5			79/92
				12.5	50/100
Foucher et al[53]
	CLD	7.2			90/52
			12.5		90/80
				17.6	91/92
Gomez-Dominguez et al[54]
	CLD	4.0			88/50
			11.0		78/76
				16.0	80/98
Kim et al[55]
	CLD	7.3			96/50
			8.8		78/95
				15.0	33/97
Arena et al[56]
	HCV	7.8			83/79
			10.8		89/95
				14.8	73/98

CLD: Chronic liver disease; post-LT: After liver transplantation; HCV: Hepatitis C virus; PPV: Positive predictive value; NPV: Negative predictive value.