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Copyright ©The Author(s) 2016.
World J Gastroenterol. Jan 28, 2016; 22(4): 1711-1720
Published online Jan 28, 2016. doi: 10.3748/wjg.v22.i4.1711
Table 1 Cut-off values of the first indirect markers of fibrosis in the diagnosis of significant fibrosis and cirrhosis1
Cut-off values of some indirect markers
MarkersAlgorithmAetiologySignificant fibrosisExtensive fibrosis or cirrhosis
APRIHCV> 1.5≥ 2
Wai et al[20], 2003AST (UI/L)/platelet count (109/L) × 100
FORNS INDEXHCV> 6.9
Forns et al[21], 20027.811-3.131 × ln (platelet count) + 0.781 × ln (GGT) + 3.467 × ln (age [years]) - 0.014 × ln (cholesterol)
FIBROTEST®Imbert-Bismut et al[22], 2001Formula combining α-2-macroglobulin, γGT, apolipoprotein A1, haptoglobin, total bilirubin, age and genderHCV≥ 0.6
LOK Lok et al[23], 2005Log odds = -5.56-0.0089 × platelet count (× 103/mm3) + 1.26 × AST/ALT ratio + 5.27 × INRHCV≥ 0.5
FIBROINDEXCLD≥ 2.25
Koda et al[24], 20071.738-0.064 [platelet counts (104/mm3)] + 0.005 × AST (UI/L) + 0.463 [gamma-globulin (g/dL)]
FIB-4CLD> 3.25
Vallet-Pichard et al[25], 2007Age (yr) × AST (UI/L)/[platelet count (109/L)] × [ALT (UI/L)]1/2