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Copyright ©The Author(s) 2016.
World J Gastroenterol. Jan 28, 2016; 22(4): 1421-1432
Published online Jan 28, 2016. doi: 10.3748/wjg.v22.i4.1421
Table 2 Recommendations for therapy in patients with genotype 1b
Patient characterizationRecommendedDurationScientific evidenceReal-world evidence
Genotype 1b naive noncirrhoticSOF + LDV12ION-1
SOF + LDV (CV < 6 × 106 UI/mL)8ION-3
OBV + PTVR + DSV12SAPHIRE I PEARL
SOF + SIM12COSMOSTARGET TRIO
SOF + DCV12
SOF + PEG + RBV12NEUTRINO
Genotype 1b naive cirrhoticSOF + LDV12ION-1
OBV + PTVR + DSV + RBV12TURQUOISE-II PEARL
SOF + SIM12COSMOS
SOF + DCV12
SOF + PEG + RBV12NEUTRINO
Genotype 1b retreated noncirrhoticSOF + LDV12ION-2
OBV + PTVR + DSV12SAPHIRE-II
SOF + SIM12COSMOS
SOF + DCV12/24
Genotype 1b retreated cirrhoticSOF + LDV + RBV12ION-2
SOF + LDV24ION-2
OBV + PTVR + DSV + RBV12TURQUOISE-II PEARL
SOF + SIM12COSMOS
SOF + DVC24