Childhood chronic gastritis and duodenitis: Role of altered sensory neuromediators

Figure 2 Substance P levels in the control (n = 30) and study (n = 52) groups. A: Substance P (SP) levels were significantly higher in the gastric mucosa from sites with severe gastritis (S1) (a) than in the control group in both the first and second extractions (b) (P = 0.001 and 0.004, respectively). SP levels were significantly higher in S1 (a) sites than in areas with less severe gastritis (S2) (c) in both extractions (P = 0.006 and 0.001, respectively). However, there were no significant differences in the SP levels between the S1 and S2 samples in both the first and second extractions (P = 0.81 and 0.99, respectively); B: There were no significant differences in the SP levels between H. pylori (+) and H. pylori (-) patients; C: SP levels were significantly higher in patients with high-grade gastritis. H. pylori: Helicobacter pylori.