Inflammatory bowel disease in India - Past, present and future

Table 3 Comparative data on ulcerative colitis related colorectal cancer in different Indian series

Study type	Incidence of CRC	Time duration of FU in years	Presented with CRC	CRC developed at FU	Risk of CRC at time in years	Risk Factors	LGD	HGD	Detected on surveillance/symptoms
Retrospective[91]	8/436 (1.8%)	12.1 (7-25)	4	4 (2/4 after 7, 8 yr of FU)		Pancolitis 6/8 (66.7%)	NM	NM	Symptoms
Retrospective[90]	5/532 (0.94%)	25	0	5 (in FU of 6 yr)	0 at 10, 2.3% (4.4% for pancolitis) at 20, 5.8% (10.2% for pancolitis) at > 20	Pancolitis, disease duration > 10 yr	2 progressed to CRC (1 after 5 yr, 1 at a different site after 1 yr). 6 did not progress in 1- 2 1/2 yr	2 (1 CRC after 3 yr, another operated immediately)	2 CRC on routine surveillance
Partly Retrospective, partly prospective[1]	5/50 (10%), [0/21 (prospective), 5/19 (retrospective)]	9.35 (1-30), prospective 4.5 (1-12), retrospective 15 (8-30)	0	5 (1 after 10 yr, 4 after 20 yr)	0 at 10, 1% at 20, 7% at > 20	Disease duration > 10 yr	No surveillance	No surveillance	5 at symptoms
Prospective[93]	12/430 (2.8%)	Median 6 (1-39)	0	After median 18 yr from onset (6-27), 3 at 6, 6, 7 yr FU	Incidence density per 103 PYD was 2.3 at 10, 3.3 at 20 , 7 at > 20	Pancolitis, longer disease duration	NM	NM	1 on surveillance after 11 yr/11 at symptoms, (unifocal in 10 and multifocal in 2)
Prospective surveillance study[92]	1/29 (3.4%)	10 (7.5-14.5)	0	1 (after 1 yr)		Pancolitis in 55%	5 at baseline, 3 new cases on surveillance	3 (1 CRC after 1 yr)	1 over 42 mo surveillance

CRC: Colorectal cancer; FU: Follow up; LGD: Low grade dysplasia; HGD: High grade dysplasia; PYD: Person years of disease duration; NM: Not mentioned.