Nicotinic cholinergic receptors in esophagus: Early alteration during carcinogenesis and prognostic value

Figure 3 Receiver operating characteristic curve for the discrimination of healthy esophagus and normal-appearing surrounding tissue of esophageal squamous cell carcinoma patients, according to CHRNB4 expression. The receiver operating characteristic curve was performed for CHRNB4 mRNA expression normalized with GAPDH (number of healthy individuals: 32, number of esophageal squamous cell carcinoma patients: 19). For a CHRNB4 expression cut-off of 1.429 × 10^-5, the area under the curve was 0.824, with a sensitivity of 75.86% and a specificity of 78.95%, P = 0.0002.