Retrospective Cohort Study
Copyright ©The Author(s) 2016.
World J Gastroenterol. Aug 21, 2016; 22(31): 7146-7156
Published online Aug 21, 2016. doi: 10.3748/wjg.v22.i31.7146
Table 5 Association of CHRN expression fold-change and clinicopathological data of esophageal squamous cell carcinoma patients
ClinicopathologicaldataCHRNA3
CHRNA5
CHRNA7
CHRNB4
FC,P valueFC,P valueFC,P valueFC,P value
medianmedianmedianmedian
(min-max)(min-max)(min-max)(min-max)
Age, yr6059.559.560
(46-79)(46-79)(46-79)(46-79)
> median1.10.27752.1660.16122.8670.94511.9840.1128
(0.03136-14.69)(0.3918-15.07)(0.2630-20.53)(0.1586-7.119)
≤ median0.58443.1931.2670.7518
(0.006324-10.62)(0.8615-11.66)(0.4813-23.10)(0.1414-2.051)
Sex
Men0.97770.10533.0320.17192.8670.71921.6850.1053
(0.006324-14.69)(0.3918-15.07)(0.4813-23.10)(0.2261-7.119)
Women0.11532.1021.6570.3153
(0.03349-1.072 )(0.5510-3.593)(0.2630-20.53)(0.1414-2.809)
Smoking
NeverNANANANANANANANA
Ever0.69413.011.861.229
(0.006324-14.69)(0.3918 - 15.07)(0.2630-23.10)(0.1414-7.119)
Alcohol consumption
NeverNANANANANANANANA
Ever0.58442.9711.6570.9571
(0.006324-14.69)(0.3918-15.07)(0.2630-23.10)(0.1414-7.119)
Tumor localization1
Upper third0.11530.40791.5890.07370.82550.15250.39640.3510
(0.03136-14.69)(0.3918- 6.284)(0.2630-7.917)(0.1414-7.119)
Middle third0.82653.012.5671.5
(0.006324-10.62)(0.8615-11.66)(0.4813-23.10)(0.2261-2.809)
Lower third3.9049.3294.1992.211
(0.07381-7.799)(3.414-15.07)(0.7220-13.36)(1.613-2.552)
Histological grade, differentiation
WellNA0.4902NA0.9767NA0.3661NA0.8610
Moderate0.80393.0311.4540.9571
(0.03136-14.69)(0.3918-15.07)(0.2630-23.10)(0.1414-7.119)
Poor0.29082.62.5141.5
(0.006324-1.626)(1.826-4.993)(1.057-18.57)(0.5035-2.532)
Tumor stage
1 + 20.57280.95992.5050.7781.4540.77801.8320.4457
(0.03349-10.62)(1-15.07)(0.4813-20.53)(0.1414-2.809)
3 + 40.80393.013.1670.9571
(0.006324-7.799)(0.4633-6.566)(0.6082-23.10)(0.2261-2.532)