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©The Author(s) 2016.
World J Gastroenterol. Aug 21, 2016; 22(31): 7099-7110
Published online Aug 21, 2016. doi: 10.3748/wjg.v22.i31.7099
Table 1 Bioactive proteins from niche cells maintain the proliferative status in intestinal stem cells
Niche cellBioactive proteinReceptorTarget pathwayISC proliferationISC differentiation
Paneth cellWnt 3LRP5/6 and FrizzledWnt/β-catenin↑/
Paneth cellDll1/4Notch 1/2Notch↑↓
Paneth cellEGFEGFRRas/Raf/Mek/Erk/MAPK↑/
MyofibroblastR-spondin1Lgr4/5Wnt/β-catenin↑/
MyofibroblastNogginBMP4BMP/Smad/↓


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