Hepatitis E: Discovery, global impact, control and cure

doi:10.3748/wjg.v22.i31.7030

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 21, 2016; 22(31): 7030-7045
Published online Aug 21, 2016. doi: 10.3748/wjg.v22.i31.7030

Table 2 Diagnosis of hepatitis E virus infection

Test	Method	Uses	Comments
IgM anti-HEV	ELISA	Acute infection	Assays vary in performance, issue of genotype applicability, poor performance in immune disorders, cross-reactive with other viral infections
IgM anti-HEV	ICT (POCT)	Acute infection
IgG anti-HEV	ELISA	Seroprevalence	Assays vary in performance
	ICT (POCT)	Acute infection
		Natural protection
		Vaccine efficacy
HEV RNA	NAT	Acute infection	Viremia short-lasting, in-house assays vary in performance, advantage immune disorders
		Confirm chronicity
		Anti-viral response
		Donor screening
HEV antigen	EIA	Acute infection	81% concordance with HEV RNA

Adopted from Khuroo et al[143], 2016. HEV: Hepatitis E virus; ICT: Immunochromatographic test; POCT: Point of care test; NAT: Nucleic acid test; EIA: Enzyme immunoassay.

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Citation: Khuroo MS, Khuroo MS, Khuroo NS. Hepatitis E: Discovery, global impact, control and cure. World J Gastroenterol 2016; 22(31): 7030-7045
URL: https://www.wjgnet.com/1007-9327/full/v22/i31/7030.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i31.7030

Khuroo MS, Khuroo MS, Khuroo NS. Hepatitis E: Discovery, global impact, control and cure. World J Gastroenterol 2016; 22(31): 7030-7045 [PMID: 27610014 DOI: 10.3748/wjg.v22.i31.7030]

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