Helicobacter pylori associated gastric intestinal metaplasia: Treatment and surveillance

Table 3 Pharmacological treatment of gastric intestinal metaplasia

Ref.	Intervention	Study design	Countries	Number of patients	Results
Kong et al[38], 2014	H. pylori eradication	Meta-analysis of 16 trials (including 1 RCT and 15 observational studies)	China, Japan, Italy and Columbia	3432	Antral IM: pooled WMD with 95%CI: 0.23 (0.18-0.29)
					Corpus IM: pooled WMD with 95%CI: -0.01 (-0.04-0.02)
Leung et al[42], 2006	Rofecoxib for 24 mo	RCT (vs placebo)	China	213 after H. pylori eradication	Antrum IM regression: 24.5% vs 26.9% in placebo
					Corpus IM regression 4.3% vs 2.2% in placebo
Wong et al[43], 2012	Celecoxib for 24 mo	RCT (H. pylori eradication, celecoxib or both)	China	1024 H. pylori positive	OR for regression of gastric lesions 1.72 (95%CI: 1.07-2.76)
You et al[44], 2006	Vitamins or Anti-oxidants	RCT (H. pylori eradication, vitamins or garlic supplements)	China	3365	Both vitamins and garlic supplements have no effect on gastric precancerous lesion

H. pylori: Helicobacter pylori; RCT: Randomized controlled trial; WMD: Weighted mean difference.