Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review

Table 2 Variation in frequency of the common PNPLA3 polymorphism in different regions and among different ethnic groups

Descent/ethnicity	Alleles C1	Alleles G2	Genotypes C|C	Genotypes C|G	Genotypes G|G	Allele count		Genotype count
						C allele	G allele	C|C	C|G	G|G
All (n = 2504)	73.8%	26.2%	56.9%	33.8%	9.3%	3695	1313	1424	847	233
African (n = 661)	88.2%	11.8%	78.8%	18.8%	2.4%	1166	156	521	124	16
Latin American (n = 347)	51.6%	48.4%	27.7%	47.8%	24.5%	358	336	96	166	85
Asian (n = 504)	65.0%	35.0%	44.0%	41.9%	14.1%	655	353	222	211	71
European (n = 503)	77.4%	22.6%	60.2%	34.4%	5.4%	779	227	303	173	27
Southern Asian (n = 489)	75.4%	24.6%	57.7%	35.4%	7.0%	737	241	282	173	34

¹Allele C: Wild type;

²Allele G: Variant rs738409, codes I148M protein.