Smaller tumor size is associated with poor survival in T4b colon cancer

Table 3 Univariate and multivariate survival analyses of patients from the Surveillance, Epidemiology and End Results database with T4bN0-2M0 colon cancer

Variable	Univariateanalysis		Multivariateanalysis
	5-yr CSS	P value	HR	95%CI	P value
Sex		0.404			NI
Male	46.7%
Female	49.1%
Year of diagnosis		0.339			NI
1988-1999	49.4%
2000-2003	46.6%
Race		0.184			NI
White	48.9%
Black	41.1%
Other1	48.6%
Age at diagnosis (yr)		< 0.001			< 0.001
≤ 60	51.7%		1.000	reference
> 60	44.8%		1.309	1.148-1.492
Primary site		0.001			0.061
Right colon	45.1%		1.000	reference
Left colon	52.9%		0.875	0.761-1.006
Histological type		< 0.001			0.100
Adenocarcinoma	48.5%		1.000	reference
Mucinous adenocarcinoma	49.7%		1.008	0.848-1.197
Signet-ring cell carcinoma	17.2%		1.518	1.037-2.222
Pathology grade		< 0.001			0.002
High	67.8%		1.000	reference
Moderate	51.4%		1.530	1.127-2.077
Poor	38.6%		1.729	1.258-2.376
Undifferentiated	25.0%		2.526	1.389-4.596
N stage		< 0.001			< 0.001
N0	69.5%		1.000	reference
N1	43.7%		1.857	1.559-2.212
N2	22.5%		3.600	3.056-4.239
LNH		0.001			0.009
≤ 18	43.5%		1.000	reference
> 18	53.2%		0.841	0.738-0.959
Tumor size, cm		< 0.001			0.024
≤ 4.0	37.1%		1.000	reference
4.0-7.0	47.0%		0.820	0.683-0.985	0.034
≥ 7.0	52.5%		0.775	0.645-0.932	0.007

¹Includes Native American, Asian, Pacific Islander and Unknown. CSS: Cancer-specific survival; LNH: Number of lymph nodes harvested; NI: Not included in the multivariate survival analysis.