Re-evaluation of classical prognostic factors in resectable ductal adenocarcinoma of the pancreas

Table 1 Tumor size and survival for resectable pancreatic cancer

Ref.	Year	n	Tumor size, cut-off	Median OS	Statistical model	HR (95%CI)	P value
Matsumoto et al[38]	2015	968	≥ 3 cm	NR	Multivariable	1.72 (1.16-2.56)	0.006
Jeong et al[39]	2015	276	≤ 2.5 cm	13 mo	Multivariable	1.65 (1.17–2.32)	0.004
			> 2.5 cm	25 mo
Hur et al[17]	2015	18338	In situ	120 mo	Multivariable	1
			≤ 1.0 cm	27 mo		3.09 (2.35-4.07)	< 0.001
			1.1-2.0 cm	17 mo		4.35 (3.42-5.53)	< 0.001
			> 2.0 cm	11 mo		5.69 (4.49-7.21)	< 0.001
Yamamoto et al[40]	2015	195	≤ 2 cm	29 mo (mean)	Multivariable	0.40 (0.17-0.83)	0.012
Elberm et al[41]	2015	1070	< 2 cm	19 mo	Multivariable	0.63 (0.50-0.78)	< 0.001
Liu et al[31]	2015	411	> 2 cm	NR	Univariable	1.46 (1.14-1.88)	0.003
Okada et al[42]	2014	200	≥ 3 cm	NR	Multivariable	3.26 (1.52–7.00)	0.002
Dusch et al[21]	2014	415	< 3 cm	16 mo	Univariable	-	< 0.03
Shin et al[15]	2014	537	≤ 3 cm	22 mo	Multivariable	1.4 (1.13-1.73)	0.002
			> 3 cm	14 mo
Kooby et al[37]	2014	1399	Continuous	20 mo	Multivariable	1.12 (1.06-1.18)	< 0.001
Petermann et al[10]	2013	114	≤ 2 cm	35 mo	Multivariable	0.52 (0.25–1.05)	0.071
			2.1–3.4 cm	16 mo
			3.5–4.5 cm	20 mo
			> 4.5 cm	8 mo
Jamieson et al[43]	2013	217	≤ 3 cm	23 mo	Multivariable	1.28 (0.93–1.76)	0.13
			> 3 cm	16 mo
Franko et al[14]	2013	7135	≤ 1 cm	N0/N1: 38/18 mo	Multivariable	1
			1.1–2 cm	N0/N1: 26/19 mo		1.18 (0.94-1.48)	0.152
			> 2 cm	N0/N1: 19/14 mo		1.67 (1.34-2.07)	< 0.001
Lad et al[44]	2013	382	Continuous	16 mo	Multivariable	1.23 (1.07–1.41)	0.003
Sugiura et al[45]	2013	208	≥ 3 cm	NR	Univariable	NR	0.014
Hong et al[18]	2012	209	< 3 cm	20 mo	Univariable	NR	0.06
			≥ 3 cm	15 mo
Bhatti et al[46]	2010	84	≤ 2 cm	34 mo	Univariable	NR	0.017
			> 2 cm, invasion-	27 mo
			> 2 cm, invasion+	11 mo
Yamada et al[47]	2009	335	> 4 cm	NR	Multivariable	2.69 (1.30-5.56)	< 0.05
Ueda et al[48]	2009	140	< 3 cm	22 mo	Multivariable	1.85 (1.14-3.10)	0.013
			≥ 3 cm	11 mo
Kaneoka et al[49]	2009	84	< 2 cm	NR	Multivariable	1
			2–4 cm	20 mo		1.7 (1.0–3.1)	0.031
			> 4 cm	11 mo		2.3 (1.3–4.5)	0.003
Campbell et al[50]	2009	163	Continuous	14 mo	Multivariable	1.02 (1.00-1.03)	0.049
Doi et al[51]	2007	133	≤ 4 cm	45% dead within 1 yr	Univariable	1.55 (1.06–2.24)	0.02
			> 4 cm	67% dead within 1 yr
Zacharias et al[52]	2007	81	≤ 3 cm	28 mo	Multivariable	1.9 (1.1–3.1)	0.018
			> 3 cm	14 mo
Pawlik et al[6]	2007	905	≥ 2 cm	17 mo	Multivariable	1.24 (1.01-0.51)	0.04
Moon et al[53]	2006	94	< 3 cm	25 mo	Multivariable	0.46 (0.27-0.78)	0.004
Cleary et al[20]	2004	123	Continuous	14 mo	Univariable	1.2 (1.0–1.4)	0.01
Ahmad et al[54]	2001	125	< 2 cm	16 mo	Univariable	1
			2-4 cm			1.05 (0.58-1.89)	0.87
			> 4 cm			1.15 (0.61-2.15)	0.66
Sohn et al[55]	2000	616	< 3 cm	21 mo	Multivariable	0.72 (0.57-0.90)	0.004
			≥ 3 cm	14 mo
Meyer et al[56]	2000	113	≤ 2 cm	28 mo	Multivariable	2.27	< 0.006
			> 2 cm	13 mo

OS: Overall survival.