Effectiveness of exercise in hepatic fat mobilization in non-alcoholic fatty liver disease: Systematic review

Table 1 General characteristic of studies included

Ref.	Number of subjects with NAFLD	Age (mean)	Sex (male, %)	BMI (mean)	Primary measure	Exercise intervention	Dietary intervention	Program length	Session frequency (wk)	Exercise session duration (min)
Hallsworth et al[27], 2011	21	AE: 52	NR	AE: 32.3	H-MRS	RE	No	8 wk	3	45-60
		C: 62		C: 32.3
Sullivan et al[28], 2012	33	E: 49	AE: 33	AE: 37.1	H-MRS	AE	No	16 wk	5	30-60
		C: 48	C: 17	C: 40
Bacchi et al[29], 2013	40	AE: 56	AE: 71	AE: 30.5	H-MRS	AE and RE	No	4 mo	3	60
		RE: 56	RE: 71	RE: 28.8
Eckard et al[33], 2013	56	LFDE: 44	LFDE: 50	LFDE: 32.7	Liver biopsy	AE	Yes	6 mo	4-7	20-60
		MFDE: 55	MFDE: 67	MFDE: 40.3
		ME: 52	ME:67	ME: 31.3
		C: 51	C: 64	C: 34.7
Wong et al[12], 2013	154	AE: 51	AE: 52	AE: 51	H-MRS,	AE	Yes	12 mo	3-5	30
		C: 26	C: 41	C: 25.3	Fibroscan
Pugh et al[30], 2014	31	AE: 48	AE: 54	AE: 31	H-MRS	AE	No	16 wk	3	30-45
		C: 47	C: 50	C: 30
Cuthbertson et al[31], 2016	69	AE: 50	AE: 77	AE: 30.6	H-MRS	AE	No	16 wk	3-5	30-45
		C: 52	C: 80	C: 29.7
Hallsworth et al[32], 2015	29	AE: 54	NR	AE: 31	H-MRS	AE	No	12 wk	3	30-40
		C: 52		C: 31

AE: Aerobic exercise; RE: Resistance exercise; C: Control; LFDE: Low-fat diet plus moderate exercise; MFDE: Moderate-fat diet plus moderate exercise; ME: Moderate exercise; NR: Not reported; RT: Randomized trial; BMI: Body mass index; NAFLD: Non-alcoholic fatty liver disease; H-MRS: Hydrogen-magnetic resonance spectroscopy.