Immunohistochemistry panel segregates molecular types of hepatocellular carcinoma in Brazilian autopsy cases

Table 2 Clinicopathological features of 80 hepatocellular carcinoma autopsy cases

Feature	n (%)
Sex
Male	62 (77.5)
Female	18 (22.5)
Age, yr
Median	59.5
Range	28-82
With cirrhotic liver	72 (90.0)
With incidental small HCC, < 2.0 cm	4 (5.0)
Etiology
HCV only	27 (33.7)
HCV + alcohol	9 (11.2)
HCV + HBV	2 (2.5)
HCV + HBV + alcohol	1 (1.3)
Alcohol only	11 (13.8)
HBV only	9 (11.2)
HBV + alcohol	3 (3.8)
Hemochromatosis	2 (2.5)
Cryptogenic	10 (12.5)
Data not available	6 (7.5)
Larger tumor size, cm
Median	4
Range	0.8-18.0
Non-available/non-sizable cases	22 (27.5)
Number of tumor nodules
1	24 (33.3)
2	4 (5.6)
3	1 (1.4)
≥ 4	43 (53.8)
Non-available/uncountable cases	8 (10.0)
Gross pattern
Nodular	31 (38.8)
Massive with satellite lesions	25 (31.3)
Diffuse	8 (10.0)
Non-available/non-sizable cases	11 (13.8)
Histological grade, Edmondson-Steiner grade
1 + 2	22 (27.5)
3	47 (58.8)
4	11 (13.8)
Predominant histological pattern or variant
Trabecular	36 (45.0)
Acinar/pseudoacinar	9 (11.2)
Solid/macrotrabecular	24 (30.0)
Mixed	9 (11.2)
Clear cell	2 (2.5)

HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma; HCV: Hepatitis C virus.